Thionyl Chloride → 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionyl chloride hydrochloride

반응식

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([OH:18])=O)=[CH:10][CH:9]=1.S(Cl)([Cl:21])=O>>[ClH:21].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([Cl:21])=[O:18])=[CH:10][CH:9]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 685351183-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionic acid

생성물 1

HCID 866381233-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionyl chloride hydrochloride

실험 절차

The title compound was prepared in quantitative yield by boiling 3-[6-(2-fluoro-phenyl)-pyridin-3-yl]-propionic acid in thionyl chloride, followed by removal of the volatiles by coevaporating three times with toluene.

후처리

customfollowed by removal of the volatiles

출처 및 근거

ORD 기록: ord-a44ee74777e746109468df1306419541
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188291B2

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