Trifluoroacetic acid → [4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt

HRID 1931422노트

반응식

HRID 1931422 반응식
C([O:5][C:6](=[O:21])[CH2:7][NH:8][C:9]1[S:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[N:13]=1)(C)(C)C.[C:22]([OH:28])([C:24]([F:27])([F:26])[F:25])=[O:23]>>[F:25][C:24]([F:27])([F:26])[C:22]([OH:28])=[O:23].[F:20][C:17]1[CH:16]=[CH:15][C:14]([C:12]2[N:13]=[C:9]([NH:8][CH2:7][C:6]([OH:21])=[O:5])[S:10][CH:11]=2)=[CH:19][CH:18]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 86638125HCID 86638125, 화합물

생성물 1

HCID 44184931[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt

실험 절차

780 mg (2.53 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid tert-butyl ester in 10 ml of 90% aqueous TFA were allowed to stand at room temperature for 3 h. The mixture was concentrated and lyophilized. Yield: 859 mg.

후처리

  1. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-1e34da5915284aa3be95a8916276ef6d
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188291B2

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