2-Aminopyridine → 2-[6-(4-Fluoro-phenyl)-pyridin-3-yloxy]-N-(pyridin-2-yl)-acetamide trifluoroacetic acid salt

HRID 1931461노트

반응식

HRID 1931461 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.[NH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)=[O:25])=[CH:17][CH:16]=2)=[CH:13][CH:14]=1

참가 물질

3

반응물 2

HCID 104392-AminopyridineHCID 68534898[6-(4-Fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt

생성물 1

HCID 685351082-[6-(4-Fluoro-phenyl)-pyridin-3-yloxy]-N-(pyridin-2-yl)-acetamide trifluoroacetic acid salt

실험 절차

The title compound was prepared analogously as described in Example 30(d) from 95 mg (0.26 mmol) of [6-(4-fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt and 39.5 mg (0.39 mmol) of 2-aminopyridine. Yield: 9.3 mg.

출처 및 근거

ORD 기록
ord-09332a6040ee41798c9607096351122d
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188291B2

반응 노트

불러오는 중…