Dimethylformamide diethylacetal → HCID 178484337, 화합물

HRID 1931547노트

반응식

HRID 1931547 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH2:7])=[O:6].C(O[CH:14](OCC)[N:15]([CH3:17])[CH3:16])C>>[Br:1][C:2]1[CH:3]=[C:4]([C:5](/[N:7]=[CH:14]/[N:15]([CH3:17])[CH3:16])=[O:6])[CH:8]=[CH:9][N:10]=1

참가 물질

3

반응물 2

HCID 70913Dimethylformamide diethylacetalHCID 46254072-Bromoisonicotinamide

생성물 1

HCID 178484337HCID 178484337, 화합물수율 98%

반응 조건

온도
120 °C

실험 절차

2-bromo-isonicotinamide (406.2 mg, 2.021 mmol) and N,N-dimethylformamide diethyl acetal (0.48 ml, 2.80 mmol) were combined and heated to 120° C. A short path distillation apparatus was used to collect the ethanol that was liberated during the reaction. The reaction mixture was a light orange solution that slowly turned darker until it had become a dark amber solution. After 1.5 hours, the reaction mixture was cooled to room temperature. The reaction mixture solidified upon cooling and was placed under high vacuum overnight to give the title compound (507.4 mg) as an off-white solid.

후처리

  1. distillationA short path distillation apparatus
  2. customto collect the ethanol that
  3. customwas liberated during the reaction
  4. temperaturethe reaction mixture was cooled to room temperature
  5. temperatureupon cooling
  6. customwas placed under high vacuum overnight

출처 및 근거

ORD 기록
ord-4c08072b05fa48d28ec290fd86677c22
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188085B2

반응 노트

불러오는 중…