(1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(acetyloxy)-15-[[(2R)-2,3-dimethyl-2-(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-6-oxo-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid → (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-(methylamino)butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-[[(1-methylethyl)amino]carbonyl]-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-6-oxo-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid

반응식

[CH3:1][CH:2]([NH:4][C:5]([C:7]1[N:11]=[CH:10][NH:9][N:8]=1)=[O:6])[CH3:3].C(O[C@@H:16]1[CH2:48][C@:20]23[C:24]4[C@H:33]([CH2:34][CH2:35][C@H:19]2[C@@:18]([CH3:49])([CH2:23][O:22][CH2:21]3)[C@H:17]1[O:50][CH2:51][C@:52]([CH3:58])([NH:56][CH3:57])[CH:53]([CH3:55])[CH3:54])[C@:32]1([CH3:36])[C@:27]([CH3:46])([C@H:28]([C:43]([OH:45])=[O:44])[C@:29]([C@H:38]([CH3:42])[CH:39]([CH3:41])[CH3:40])([CH3:37])[CH2:30][CH2:31]1)[C:26](=[O:47])[CH:25]=4)(=O)C>ClCCCl>[CH3:58][C@@:52]([NH:56][CH3:57])([CH:53]([CH3:55])[CH3:54])[CH2:51][O:50][C@@H:17]1[C@@:18]2([CH3:49])[C@@H:19]3[CH2:35][CH2:34][C@H:33]4[C:24]([C@@:20]3([CH2:21][O:22][CH2:23]2)[CH2:48][C@H:16]1[N:8]1[C:7]([C:5]([NH:4][CH:2]([CH3:1])[CH3:3])=[O:6])=[N:11][CH:10]=[N:9]1)=[CH:25][C:26](=[O:47])[C@:27]1([CH3:46])[C@:32]4([CH3:36])[CH2:31][CH2:30][C@@:29]([C@H:38]([CH3:42])[CH:39]([CH3:40])[CH3:41])([CH3:37])[C@H:28]1[C:43]([OH:45])=[O:44]