Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalic Acid → HCID 25143818, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalic Acid | HCID 971 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Chromate | HCID 24461 | — |
| 반응물 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 반응물 | 3-(2,3-Difluorophenyl)pyrrolidin-3-ol | HCID 63988383 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | HCID 25143818 | HCID 25143818 | — |
반응 단계
Preparation according to Example 51: Enantiomer E1 of 3-(2,3-difluorophenyl)-pyrrolidin-3-ol (0.15 g, 0.75 mmol), acetonitrile (6 mL), potassium carbonate (0.208 g, 1.5 mmol) and 1-bromo-2-methoxyethane (0.07 mL, 0.75 mmol). Flash chromate-graphy on silica gel (Ethyl acetate/methanol, 10:1). Yield: 0.07 g. [α]D=+22.5°; The amine was converted to the oxalic acid salt and recrystallized from ethanol/diethyl ether/diisopropyl ether; M.p. 149-150° C.; MS m/z (relative intensity, 70 eV) 257 (M+, 1), 212 (bp), 182 (65), 127 (22), 141 (16), 213 (12).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08188301B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-a7074d322e6b4e9a9318b904d0017655 |
| 출처 메모 | uspto-grants-2012_05 |