Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 3-(3-Chloro-2-fluorophenyl)pyrrolidin-3-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Tert-butyl 3-(3-chloro-2-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate | HCID 67404349 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(3-Chloro-2-fluorophenyl)pyrrolidin-3-ol | HCID 68515744 | — |
반응 단계
Preparation according to Preparation 2: tert-Butyl 3-(3-chloro-2-fluorophenyl)-3-hydroxypyrrolidin-1-carboxylate (4.42 g, 14 mmol), dichloromethane (100 mL), trifluoroacetic acid (10 mL). Stirred for 1 h. Yield: 2.24 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08188301B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-d6c04860c10a4623b05ff2051763510e |
| 출처 메모 | uspto-grants-2012_05 |