Trifluoroacetic acid → 3-(2,3-Dichlorophenyl)pyrrolidin-3-ol

HRID 1931879노트

반응식

HRID 1931879 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1([OH:21])[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1([OH:21])[CH2:13][CH2:12][NH:11][CH2:10]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86643429tert-Butyl 3-(2,3-dichlorophenyl)-3-hydroxypyrrolidin-1-carboxylate

생성물 1

HCID 635858853-(2,3-Dichlorophenyl)pyrrolidin-3-ol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Preparation according to Preparation 2: tert-Butyl 3-(2,3-dichlorophenyl)-3-hydroxypyrrolidin-1-carboxylate (1.23 g, 3.7 mmol), dichloromethane (20 mL), trifluoroacetic acid (3 mL). Stirred for 0.5 h. Purification by HPLC on Waters OBD C18, 5 μm (MeOH/33 mM NH3, 20:80 to 0:100). Yield: 0.35 g. MS m/z (rel. intensity, 70 eV) 233 (M+, 6), 231 (M+, 10), 198 (32), 196 (bp), 75 (37), 56 (27).

후처리

  1. customPreparation
  2. customaccording to Preparation 2
  3. customPurification by HPLC on Waters OBD C18, 5 μm (MeOH/33 mM NH3, 20:80 to 0:100)

출처 및 근거

ORD 기록
ord-7573fcd9f8aa4b12ae8d83edc94db375
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188301B2

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