Thionyl Chloride → 3-(Tribromomethanesulfonyl)benzoyl chloride

HRID 1934298노트

반응식

HRID 1934298 반응식
[Br:1][C:2]([Br:16])([Br:15])[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9](O)=[O:10])(=[O:5])=[O:4].S(Cl)([Cl:19])=O>CN(C)C=O>[Br:1][C:2]([Br:16])([Br:15])[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9]([Cl:19])=[O:10])(=[O:5])=[O:4]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 224660403-(Tribromomethanesulfonyl)benzoic acid

생성물 1

HCID 224660413-(Tribromomethanesulfonyl)benzoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 3-tribromomethanesulfonylbenzoic acid (B) obtained in the above-described (Step 1) are added dimethylformamide and thionyl chloride and the mixture is refluxed for one hour. The reaction mixture is filtered, and hexane is added to the filtrate to deposit crystals. The crystals are recovered by filtration and dried to obtain 3-tribromomethanesulfonyl benzoylchloride (C) as white crystals.

후처리

  1. temperaturethe mixture is refluxed for one hour
  2. filtrationThe reaction mixture is filtered
  3. additionhexane is added to the filtrate to deposit crystals
  4. filtrationThe crystals are recovered by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-07448194152749d2a650137d5297eaea
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06383731B2

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