Thionyl Chloride → 3-(Tribromomethanesulfonyl)benzoyl chloride

HRID 1934299노트

반응식

HRID 1934299 반응식
[Br:1][C:2]([Br:16])([Br:15])[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9](O)=[O:10])(=[O:5])=[O:4].S(Cl)([Cl:19])=O>CN(C)C=O>[Br:1][C:2]([Br:16])([Br:15])[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9]([Cl:19])=[O:10])(=[O:5])=[O:4]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 224660403-(Tribromomethanesulfonyl)benzoic acid

생성물 1

HCID 224660413-(Tribromomethanesulfonyl)benzoyl chloride수율 94%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 375 g (0.86 mole) of 3-tribromomethanesulfonyl benzoic acid were added 1 ml of dimethylformamide and 500 ml of thionyl chloride and the mixture was refluxed for one hour. The reaction mixture was filtered and 3000 ml of hexane was added to the filtrate to precipitate crystals. The crystals were recovered by filtration and dried to obtain 366 g of 3-tribromomethanesulfonyl benzoylchloride (yield 94%, white crystals).

후처리

  1. temperaturethe mixture was refluxed for one hour
  2. filtrationThe reaction mixture was filtered
  3. addition3000 ml of hexane was added to the filtrate
  4. customto precipitate crystals
  5. filtrationThe crystals were recovered by filtration
  6. customdried

출처 및 근거

ORD 기록
ord-52cce440902b464aaab2bb83479dbb9c
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06383731B2

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