HCID 18738447, 화합물 → 3-((dimethylamino)sulfonyl]-2(R)-methylpropionic acid
반응식
[CH3:1][N:2]([CH3:19])[S:3]([CH2:6][C@H:7]([CH3:18])[C:8]([O:10]CC1C=CC=CC=1)=[O:9])(=[O:5])=[O:4]>C(O)(=O)C.[Pd]>[CH3:19][N:2]([CH3:1])[S:3]([CH2:6][C@H:7]([CH3:18])[C:8]([OH:10])=[O:9])(=[O:4])=[O:5]참가 물질
4
실험 절차
A 100 mL Fisher/Porter vessel was charged with 1.4 g of benzyl 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionate in 30 mL acetic acid with a catalytic amount of 10% Pd—C. The reaction was hydrogenated at 50 psi for 24 hours, filtered through Celite and concentrated in vacuo. The residue was azeotroped with toluene then concentrated in vacuo to afford 900 mg of 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionic acid which was used without further purification.
후처리
- filtrationfiltered through Celite
- concentrationconcentrated in vacuo
- customThe residue was azeotroped with toluene
- concentrationthen concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-686b36f125654dfea51f842c304663dd
- 출처 데이터셋
- uspto-grants-2002_05
- 특허 번호
- US06384036B1
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