Formaldehyde → HCID 53746566, 화합물

HRID 1934571노트

반응식

HRID 1934571 반응식
C=O.[O:3]=[C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]([C:13]([OH:15])=[O:14])[CH2:5]1.N1CCCC[CH2:17]1.[CH3:22][O:23][C:24](=[O:32])[C@H:25]([CH2:30][SH:31])[NH:26][C:27](=[O:29])[CH3:28]>C(O)C>[C:27]([NH:26][C@H:25]([C:24]([O:23][CH3:22])=[O:32])[CH2:30][S:31][CH2:17][CH:5]1[C:4](=[O:3])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]1[C:13]([OH:15])=[O:14])(=[O:29])[CH3:28]

참가 물질

6

반응물 4

HCID 712FormaldehydeHCID 8082PiperidineHCID 998151H-Indene-1-carboxylic acid, 2,3-dihydro-3-oxo-HCID 6542158L-Cysteine, N-acetyl-, methyl ester

생성물 1

HCID 53746566HCID 53746566, 화합물수율 37.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

After 37% formalin (0.088 ml, 1.08 mmol) was added to a mixture of 3-oxo-1-indanecarboxylic acid (191 mg, 1.08 mmol) and piperidine (92.3 mg, 1.08 mmol), the mixture was stirred at room temperature for 3 hours. The reaction solution was concentrated. Ethanol (3 ml) and N-acetyl-L-cysteine methyl ester (80 mg, 0.45 mmol) were added to the residue. The mixture was heated to reflux for 10 minutes and then concentrated in vacuo. The residue was purified by silica gel column chromatography (100 ml, chloroform:methanol:acetic acid=30:1:0.5) to give Compound (6A) (62 mg, yield: 15.7%).

후처리

  1. concentrationThe reaction solution was concentrated
  2. temperatureThe mixture was heated
  3. temperatureto reflux for 10 minutes
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by silica gel column chromatography (100 ml, chloroform:methanol:acetic acid=30:1:0.5)

출처 및 근거

ORD 기록
ord-b8c4222dff4f4359b2551b9bcea2f8d1
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06384063B1

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