Z-L-Dap(boc)-OL → (S)-tert-Butyl (2-amino-3-hydroxypropyl)carbamate

HRID 1934685노트

반응식

HRID 1934685 반응식
C(OC([NH:11][C@@H:12]([CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][OH:14])=O)C1C=CC=CC=1>[Pd].CO.O1CCOCC1>[NH2:11][C@@H:12]([CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][OH:14]

참가 물질

5

반응물 1

HCID 10734767Z-L-Dap(boc)-OL

생성물 1

HCID 10702853(S)-tert-Butyl (2-amino-3-hydroxypropyl)carbamate수율 105.8%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

10% Palladium on activated carbon (10 mg) was added to a solution of (S)-2-(benzyloxycarbonylamino)-3-(tert-butoxycarbonylamino)propanol (920 mg) in methanol (10 mL) and dioxane (1 mL). The mixture was stirred under hydrogen atmosphere (3.5 atm) for one and a half days at ambient temperature. The catalyst was removed by filtration and the filtrate was concentrated in vacuo. The residue was dissolved in ethyl acetate, dried over magnesium sulfate, and concentrated in vacuo to give (S)-2-amino-3-(tert-butoxycarbonylamino)propanol (571 mg) as a white solid substance.

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2da21c72f9204bdcb25e706b8670a32d
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06384080B1

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