Ethanol → (3R)-8-(4-isopropylphenoxy)-1-thia-4-azaspiro[4.5]decane-3-carboxylic acid

HRID 1934741노트

반응식

HRID 1934741 반응식
C(O)C.[CH:4]([C:7]1[CH:20]=[CH:19][C:10]([O:11][CH:12]2[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]2)=[CH:9][CH:8]=1)([CH3:6])[CH3:5].O.Cl.[NH2:23][C@H:24]([C:27]([OH:29])=[O:28])[CH2:25][SH:26].C([O-])(=O)C.[Na+]>O>[CH:4]([C:7]1[CH:20]=[CH:19][C:10]([O:11][CH:12]2[CH2:17][CH2:16][C:15]3([S:26][CH2:25][C@@H:24]([C:27]([OH:29])=[O:28])[NH:23]3)[CH2:14][CH2:13]2)=[CH:9][CH:8]=1)([CH3:6])[CH3:5]

참가 물질

6

반응물 4

HCID 702EthanolHCID 23462L-Cysteine hydrochloride monohydrateHCID 517045Sodium AcetateHCID 224671444-(4-Isopropylphenoxy)-1-cyclohexanone

생성물 1

HCID 70156069(3R)-8-(4-isopropylphenoxy)-1-thia-4-azaspiro[4.5]decane-3-carboxylic acid수율 54.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a solvent mixture consisting of 21 ml of ethanol and 9 ml of water were dissolved 3.10 g of 4-(4-isopropylphenoxy)-1-cyclohexanone, 2.35 g of L-cysteine hydrochloride monohydrate and 1.10 g of sodium acetate. The mixture was stirred at ambient temperature for 6 hours. The reaction mixture was concentrated under reduced pressure, and water and ethyl ether were added to the concentrate. The deposited crystal was collected by filtration, and there was obtained 2.45 g of (3R)-8-(4-isopropylphenoxy)-1-thia-4-azaspiro[4.5]decan-3-carboxylic acid as a colorless crystalline product.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure, and water and ethyl ether
  2. additionwere added to the concentrate
  3. filtrationThe deposited crystal was collected by filtration

출처 및 근거

ORD 기록
ord-7a3e02c9157c49828c2b4131da2f3189
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06384065B1

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