Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-(3-Bromophenylmethylamino)-6,7-diethoxy-3-quinolinecarbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Benzenemethanamine, 3-bromo- | HCID 457587 | — |
| 반응물 | 1-Ethoxyethanol | HCID 10129898 | — |
| 반응물 | 4-Chloro-6,7-diethoxyquinoline-3-carbonitrile | HCID 10778872 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 4-(3-Bromophenylmethylamino)-6,7-diethoxy-3-quinolinecarbonitrile | HCID 22466686 | 68.5% |
반응 단계
A stirred mixture of 4-chloro-6,7-diethoxy-3-quinolinecarbonitrile (0.69 g, 2.5 mmol), 3-bromobenzylamine (0.78 g, 3.5 mmol), diisopropylethyl amine (1.05 ml, 6.0 mmol), and 7.5 ml of ethoxyethanol was refluxed for 4 h, cooled, and stirred with a mixture of hexane and water containing 0.4 g of potassium carbonate for 3 h. The resulting solid was filtered, washed with water, and dried. Recrystallization from acetone-hexane gave 0.73 g of off-white solid, mp 156-159° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06384051B1 |
| 출처 데이터셋 | uspto-grants-2002_05 |
| ORD ID | ord-a581f93e538b49cf8efb821ae04a6692 |
| 출처 메모 | uspto-grants-2002_05 |