tert-butyl-3-nitro-5-cyclopropyl-1H-pyrazole-1-carboxylate → tert-butyl 3-amino-5-cyclopropyl-1H-pyrazole-1-carboxylate
반응식
[C:1]([O:5][C:6]([N:8]1[C:12]([CH:13]2[CH2:15][CH2:14]2)=[CH:11][C:10]([N+:16]([O-])=O)=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[C:12]([CH:13]2[CH2:14][CH2:15]2)=[CH:11][C:10]([NH2:16])=[N:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]참가 물질
4
실험 절차
1.2 g (4.74 mmol) of tert-butyl-3-nitro-5-cyclopropyl-1H-pyrazole-1-carboxylate were dissolved in 20 ml of ethanol and hydrogenated in presence of 200 mg of palladium on charcoal 10% at 50 psi and room temperature to give, after filtration on celite and evaporation of the solvent, 0.96 g (95% yield) of the title compound.
후처리
- customto give
- filtrationafter filtration
출처 및 근거
- ORD 기록
- ord-f5fa94ed91264816b207650519461718
- 출처 데이터셋
- uspto-grants-2002_05
- 특허 번호
- US06387900B1
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