2,3-Diphenylpropionic acid → 2-Phenyl-2,3-dihydro-1H-inden-1-one

HRID 1935740

반응식

HRID 1935740 반응식
[C:1]1([CH:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O>[C:1]1([CH:7]2[CH2:11][C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]2=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 1

HCID 187442,3-Diphenylpropionic acid

생성물 1

HCID 3184912-Phenyl-2,3-dihydro-1H-inden-1-one

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Polyphosphoric acid (50 g) was heated in an oil bath at 140-145° C. and 2,3-diphenyl-propanoic acid (2.5 g) was added. Heating was continued for 45 min. Water was added. The mixture was cooled and extracted with ethyl acetate. The organic extracts were washed with 1 M NaOH solution and water. After drying the solvent was evaporated under reduced pressure. The product thus obtained was further purified by trituration in heptane.

후처리

  1. temperatureHeating
  2. temperatureThe mixture was cooled
  3. extractionextracted with ethyl acetate
  4. washThe organic extracts were washed with 1 M NaOH solution and water
  5. customAfter drying the solvent
  6. customwas evaporated under reduced pressure
  7. customThe product thus obtained
  8. customwas further purified by trituration in heptane

출처 및 근거

ORD 기록
ord-936efe47068f487a8c3449ba258d1285
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06388090B2

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