2,3-Diphenylpropionic acid → 2-Phenyl-2,3-dihydro-1H-inden-1-one
반응식
[C:1]1([CH:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O>[C:1]1([CH:7]2[CH2:11][C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]2=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
3
실험 절차
Polyphosphoric acid (50 g) was heated in an oil bath at 140-145° C. and 2,3-diphenyl-propanoic acid (2.5 g) was added. Heating was continued for 45 min. Water was added. The mixture was cooled and extracted with ethyl acetate. The organic extracts were washed with 1 M NaOH solution and water. After drying the solvent was evaporated under reduced pressure. The product thus obtained was further purified by trituration in heptane.
후처리
- temperatureHeating
- temperatureThe mixture was cooled
- extractionextracted with ethyl acetate
- washThe organic extracts were washed with 1 M NaOH solution and water
- customAfter drying the solvent
- customwas evaporated under reduced pressure
- customThe product thus obtained
- customwas further purified by trituration in heptane
출처 및 근거
- ORD 기록
- ord-936efe47068f487a8c3449ba258d1285
- 출처 데이터셋
- uspto-grants-2002_05
- 특허 번호
- US06388090B2
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