2-Phenyl-2,3-dihydro-1H-inden-1-one → 1-Benzyl-5-(2-phenylindan-1-ylidenemethyl)-1H-imidazole

HRID 1935741

반응식

HRID 1935741 반응식
[CH2:1]([N:8]1[C:12]([CH:13]=[C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20](OC)[CH:21]=3)[CH2:16][CH:15]2[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C2CC3C(=CC=CC=3)C2=O)C=CC=CC=1>>[CH2:1]([N:8]1[C:12]([CH:13]=[C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][CH:15]2[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 3184912-Phenyl-2,3-dihydro-1H-inden-1-oneHCID 698324681-benzyl-5-(6-methoxy-2-phenylindan-1-ylidenemethyl)-1H-imidazole

생성물 1

HCID 698316891-Benzyl-5-(2-phenylindan-1-ylidenemethyl)-1H-imidazole

실험 절차

1-Benzyl-5-(2-phenylindan-1-ylidenemethyl)-1H-imidazole was prepared as 1-benzyl-5-(6-methoxy-2-phenylindan-1-ylidenemethyl)-1H-imidazole above except that 2-phen-ylindan-1-one was used as a starting material. In this case after evaporation of the filtrate the residue was dissolved in diluted hydrochloric acid. The product was extracted into dichloromethane. The combined organic phases were washed with water, dried over sodium sulfate and evaporated under reduced pressure. The crude product as its hydrochloride salt was used in the next step without purification.

후처리

  1. customIn this case after evaporation of the filtrate the residue
  2. dissolutionwas dissolved in diluted hydrochloric acid
  3. extractionThe product was extracted into dichloromethane
  4. washThe combined organic phases were washed with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated under reduced pressure
  7. customThe crude product as its hydrochloride salt was used in the next step without purification

출처 및 근거

ORD 기록
ord-a2772c0c079b4591a42e9ac8edab933c
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06388090B2

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