Oxalyl chloride → 2-Ethyl-6-methylbenzoyl chloride
반응식
[CH2:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:4]=1[C:5](O)=[O:6])[CH3:2].C(Cl)(=O)C([Cl:16])=O>ClCCl.CN(C=O)C>[CH2:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:4]=1[C:5]([Cl:16])=[O:6])[CH3:2]참가 물질
5
실험 절차
A solution of 2-ethyl-6-methylbenzoic acid (49 mg, 0.30 mmol) in dichloromethane (3 mL) containing DMF (1 drop) was treated with oxalyl chloride (0.14 mL, 1.6 mmol) and the mixture was stirred for 15 h. The mixture was concentrated, azeotroping with toluene to remove traces of oxalyl chloride and the residue was used directly in the next step.
후처리
- concentrationThe mixture was concentrated
- customazeotroping with toluene
- customto remove traces of oxalyl chloride
출처 및 근거
- ORD 기록
- ord-8863ec9453634770aa1fdd50a41a75a2
- 출처 데이터셋
- uspto-grants-2002_05
- 특허 번호
- US06388084B1
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