Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1937416생성일: 2026년 10월 26일
2-Chloro-N,N-dimethylpyrimidin-4-amine → N4,N4-dimethyl-N2-[1-(2-phenylethyl)-4-piperidinyl]-2,4-pyrimidinediamine
https://huagongshe.com/reaction/1937416
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Chloro-N,N-dimethylpyrimidin-4-amine | HCID 95975 | — |
| 반응물 | 1-(2-Phenylethyl)piperidin-4-amine | HCID 10728788 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N4,N4-dimethyl-N2-[1-(2-phenylethyl)-4-piperidinyl]-2,4-pyrimidinediamine | HCID 53921131 | 28.4% |
반응 단계
A mixture of 1-(2-phenylethyl)-4-piperidinamine (8.17 g) and 2-chloro-N,N-dimethyl-4-pyrimidinamine (6.3 g) was stirred for 20 hours at 120° C. The reaction mixture was diluted with water and extracted with CH2Cl2. The organic layer was washed with water, dried, filtered and the solvent evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH(NH3) 96/4). The pure fractions were collected and the solvent evaporated. The residue was crystallized from CH3CN. The precipitate was filtered off and dried, yielding 3.69 g (28.4%) of N4,N4-dimethyl-N2-[1-(2-phenylethyl)-4-piperidinyl]-2,4-pyrimidinediamine (comp. 11).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06395742B1 |
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| 출처 데이터셋 | uspto-grants-2002_05 |
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| ORD ID | ord-58cd85450cae421b8d8e48d75748ed99 |
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| 출처 메모 | uspto-grants-2002_05 |
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