Potassium Hydroxide → 2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

HRID 1937667노트

반응식

HRID 1937667 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][N:23]=2)[C:16]([O:18]CC)=[O:17])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[OH-].[K+]>C(O)C>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][N:23]=2)[C:16]([OH:18])=[O:17])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 16125879Ethyl 2-(3,4,5-trimethoxyphenyl)pyridine-4-carboxylate

생성물 1

HCID 120434852-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 2-(3,4,5-trimethoxyphenyl)isonicotinate (3.17 g) in ethanol (40 mL) was added 10% potassium hydroxide (2.42 g). The mixture was stirred at room temperature for 5 hours and evaporated. Water was added to the residue and pH was adjusted to 7. White precipitates of the title compound were collected by filtration and the compound was used for next step without further purification.

후처리

  1. customevaporated
  2. additionWater was added to the residue and pH
  3. customWhite precipitates of the title compound
  4. filtrationwere collected by filtration
  5. customthe compound was used for next step without further purification

출처 및 근거

ORD 기록
ord-54ea64af05b444928c6860e09896b430
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06395753B1

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