Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloropyridine → (R)-N-(2-pyridyl)-2-aminopropanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloropyridine | HCID 7977 | — |
| 반응물 | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (R)-N-(2-pyridyl)-2-aminopropanol | HCID 21339422 | 87.4% |
반응 단계
(R)-Alaninol (107.3 g, 1.43M) was added dropwise with stirring to a solution of potassium tertiary butoxide (160 g, 1.43M) in tetrahydrofuran (1L). After the exothermic reaction had cooled to room termperature, 2-chloropyridine (162.4 g, 1.43M) was added dropwise. The reaction mixture was heated under reflux overnight, cooled, filtered and evaporated to an oil. The oil was dissolved in xylene (1,5L) and toluene-p-sulphonic acid (0.5 g) was added. The mixture was heated under reflux overnight. On cooling to room temperature the product crystallised to give (R)-N-(2-pyridyl)-2-aminopropanol (190 g), [α]D26=30° (c=1 in CHCl3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06395902B1 |
| 출처 데이터셋 | uspto-grants-2002_05 |
| ORD ID | ord-567d0f352f694ca785f48c23cb95f136 |
| 출처 메모 | uspto-grants-2002_05 |