3-Nitro-7-(2-trifluoromethylbenzyloxy)quinoline → 3-Amino-7-(2-trifluoromethylbenzyloxy)quinoline

HRID 1938336노트

반응식

HRID 1938336 반응식
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([F:25])([F:24])[F:23])[CH:8]=2)([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([F:25])([F:23])[F:24])[CH:8]=2

참가 물질

4

반응물 1

HCID 214693273-Nitro-7-(2-trifluoromethylbenzyloxy)quinoline

생성물 1

HCID 214693313-Amino-7-(2-trifluoromethylbenzyloxy)quinoline

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

In ethanol (30 mL) was suspended 3-nitro-7-(2-trifluoromethylbenzyloxy)quinoline (600 mg, 1.72 mmol.), and to the suspension was added platinum oxide (72 mg). Then, catalytic reduction was performed for 3 hours. After the completion of reaction was confirmed, the reaction mixture was filtered over Celite®, and the filtrate was placed under reduced pressure to leave the desired compound as brown oil in the quantitative yield.

후처리

  1. customAfter the completion of reaction
  2. filtrationthe reaction mixture was filtered over Celite®

출처 및 근거

ORD 기록
ord-ec5422ec689e43a8bdbf528a60d38702
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693651

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