Ammonia → HCID 21469426, 화합물

HRID 1938362노트

반응식

HRID 1938362 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][CH:19]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([C:31](O)=[O:32])[CH:29]=3)[NH:24][CH:23]=2)[CH2:18][CH2:17]1.CS([O-])(=O)=O.ClC1C=CC=C[N+:41]=1C.N>CN1CCCC1=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:17][CH2:18][CH:19]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([C:31]([NH2:41])=[O:32])[CH:29]=3)[NH:24][CH:23]=2)[CH2:20][CH2:21]1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 9834448HCID 9834448, 화합물HCID 21469431HCID 21469431, 화합물

생성물 1

HCID 21469426HCID 21469426, 화합물

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

2.1 g of 3-[1-(4-(5-methoxyindol-3-yl)butyl)-4-piperidyl]indole-5-carboxylic acid are suspended in 100 ml of N-methylpyrrolidone. 3.2 g of 2-chloro-1-methylpyridinium methanesulfonate are then added and the mixture is stirred at room temperature for 12 hours. Dried NH3 gas is passed into the resulting solution until it is saturated and it is stirred again for 10 hours. Working-up in a conventional manner gives 3-[1-(4-(5-methoxyindol-3-yl)butyl)-4-piperidyl]indole-5-carboxamide.

후처리

  1. stirringit is stirred again for 10 hours

출처 및 근거

ORD 기록
ord-a9284366a8844ca7b167fbe242469312
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693655

반응 노트

불러오는 중…