7-Nitro-1,2,3,4-tetrahydroquinoline → 1,2,3,4-Tetrahydroquinolin-7-amine

HRID 1938482노트

반응식

HRID 1938482 반응식
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][NH:11]2)=[CH:6][CH:5]=1)([O-])=O>C(OCC)(=O)C>[NH2:1][C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][NH:11]2)=[CH:6][CH:5]=1

참가 물질

3

반응물 1

HCID 2525137-Nitro-1,2,3,4-tetrahydroquinoline

생성물 1

HCID 152196191,2,3,4-Tetrahydroquinolin-7-amine수율 101.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 7-nitro-1,2,3,4-tetrahydroquinoline (396 mg, 0.0022 mol) in 4 mL of ethyl acetate was hydrogenated under an atmosphere of hydrogen with PdC 10% (40 mg) at rt for 2 h. Filtration over celite afforded 330 mg (100%) of 7-amino-1,2,3,4-tetrahydroquinoline. Data for 7-amino-1,2,3,4-tetrahydroquinoline: 1H NMR (400 MHz, CDCl3) 6.72 (d, J=7.9, 1H), 6.00 (dd, J=7.9, 2.3, 1H), 5.84 (d, J=2.3, 1H), 3.67 (bs, 1H), 3.42 (bs, 2H), 3.24 (t, J=5.0, 2H), 2.65 (t, J=6.4, 2H), 1.91 (quintet, J=6.0 Hz. 2H).

후처리

  1. filtrationFiltration

출처 및 근거

ORD 기록
ord-3ea1a70046964c4f9d53979711ad5f61
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693647

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