Isopropanol → 2-Morpholino-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline

HRID 1938540노트

반응식

HRID 1938540 반응식
Cl[C:2]1[N:11]=[C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]3[O:20][CH2:21][O:22][C:16]=3[CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]#[N:24])[CH:8]=2)[N:3]=1.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1.C(O)(C)C>O>[O:28]1[CH2:29][CH2:30][N:25]([C:2]2[N:11]=[C:10]([NH:12][CH2:13][C:14]3[CH:19]=[CH:18][C:17]4[O:20][CH2:21][O:22][C:16]=4[CH:15]=3)[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([C:23]#[N:24])[CH:8]=3)[N:3]=2)[CH2:26][CH2:27]1

참가 물질

5

반응물 3

HCID 3776IsopropanolHCID 8083MorpholineHCID 211839842-Chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline

생성물 1

HCID 211840382-Morpholino-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline수율 79.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture comprising 338 mg of 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline, 435 mg of morpholine and 20 ml of isopropyl alcohol was heated under reflux for 3 hours, followed by the addition of 30 ml of water under heating. The precipitate thus formed was recovered by filtration and washed with 30 ml of water and 30 ml of ethyl acetate. Thus, 310 mg of the title compound was obtained.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. temperatureunder heating
  4. customThe precipitate thus formed
  5. filtrationwas recovered by filtration
  6. washwashed with 30 ml of water and 30 ml of ethyl acetate

출처 및 근거

ORD 기록
ord-e3d8ea580f3d4ff9b4c8eac05a00ac30
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693652

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