4-(4-Phenyl-4-n-propyl-4-silacyclohexyl)cyclohexanone → 4-(4-Phenyl-4-n-propyl-4-silacyclohexyl)cyclohexyl-4'-fluorobiphenyl

HRID 1938874

반응식

HRID 1938874 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Mg]Br)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:16]1([Si:22]2([CH2:35][CH2:36][CH3:37])[CH2:27][CH2:26][CH:25]([CH:28]3[CH2:33][CH2:32][C:31](=O)[CH2:30][CH2:29]3)[CH2:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:16]1([Si:22]2([CH2:35][CH2:36][CH3:37])[CH2:27][CH2:26][CH:25]([CH:28]3[CH2:33][CH2:32][CH:31]([C:9]4[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=4[C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[CH2:30][CH2:29]3)[CH2:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

3

반응물 2

HCID 110343904-(4-Phenyl-4-n-propyl-4-silacyclohexyl)cyclohexanoneHCID 178505512HCID 178505512, 화합물

생성물 1

HCID 543968594-(4-Phenyl-4-n-propyl-4-silacyclohexyl)cyclohexyl-4'-fluorobiphenyl

실험 절차

In the same manner as in Example 6, 25 g of 4-(4-fluorophenyl)phenylmagnesium bromide was reacted with 31.5 g of 4-(4-phenyl-4-n-propyl-4-silacyclohexyl)cyclohexanone and the resultant alcohol was dehydrated, followed by catalytic reduction to obtain 4-(4-phenyl-4-n-propyl-4-silacyclohexyl)cyclohexyl-4'-fluorobiphenyl. The biphenyl product was then reacted with iodine monochloride, followed by reduction with lithium aluminohydride to obtain 14.4 g (yield: 36%) of the intended product. The product was subjected to NMR and IR analyses with the results shown below.

출처 및 근거

ORD 기록
ord-b49fd8ee404840628c97541b6e7a8946
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693841

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