Ethyl 4,4,4-trifluoro-3-oxo-2-phenylbutanoate → 6-Trifluoromethyl-3-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1939147노트

반응식

HRID 1939147 반응식
[F:1][C:2]([F:18])([F:17])[C:3]([CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8]CC)=O)=[O:4].[CH2:19]=[N:20][C:21]([CH3:31])([C:23]1[CH:28]=[C:27]([Cl:29])[CH:26]=[C:25]([Cl:30])[CH:24]=1)[CH3:22]>C1(C)C(C)=CC=CC=1>[F:18][C:2]([F:1])([F:17])[C:3]1[O:4][CH2:19][N:20]([C:21]([CH3:31])([C:23]2[CH:24]=[C:25]([Cl:30])[CH:26]=[C:27]([Cl:29])[CH:28]=2)[CH3:22])[C:6](=[O:8])[C:5]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 13913997Ethyl 4,4,4-trifluoro-3-oxo-2-phenylbutanoateHCID 21223286N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

생성물 1

HCID 212232766-Trifluoromethyl-3-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one수율 84%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

Ethyl 2-trifluoroacetyl-2-phenylacetate (1.30 g) and N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine (1.19 g) were mixed, and xylene (10 ml) was added thereto. The mixture was allowed to react by refluxing for 30 minutes. The solvent was removed by evaporation, and the crude product was recrystallized from a mixture of hexane and ethyl acetate to afford the captioned compound (1.80 g, yield 84%).

후처리

  1. customto react
  2. temperatureby refluxing for 30 minutes
  3. customThe solvent was removed by evaporation
  4. customthe crude product was recrystallized from a mixture of hexane and ethyl acetate

출처 및 근거

ORD 기록
ord-23118503df7048059f2b101b339f46a4
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05696054

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