5'-Fluoro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid → 3'-Chloro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid
반응식
FC1C=CC(OC)=C(C2C(C(O)=O)=CC([N+]([O-])=O)=CC=2)C=1.[Cl:22][C:23]1[C:24]([O:42][CH3:43])=[C:25]([C:29]2[C:30]([C:38]([O:40]C)=[O:39])=[CH:31][C:32]([N+:35]([O-:37])=[O:36])=[CH:33][CH:34]=2)[CH:26]=[CH:27][CH:28]=1>>[Cl:22][C:23]1[C:24]([O:42][CH3:43])=[C:25]([C:29]2[C:30]([C:38]([OH:40])=[O:39])=[CH:31][C:32]([N+:35]([O-:37])=[O:36])=[CH:33][CH:34]=2)[CH:26]=[CH:27][CH:28]=1참가 물질
3
실험 절차
This compound was prepared in a manner similar to that of 5'-fluoro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid (EXAMPLE 107) from methyl (3'-chloro-2'-methoxy-4-nitro-2-biphenylcarboxylate) (230 mg) to afford 0.21 g (99%) of 3'-chloro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid as a white solid. Data for 3'-chloro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid: 1H NMR (400 MHz, acetone-d6) 8.76 (d, J=2.5, 1H), 8.50 (dd, J=8.4, 2.5, 1H), 7.74 (d, J=8.5, 1H), 7.51 (dd, J=7.9, 1.8, 1H), 7.31 (dd, J=7.4, 1.8, 1H), 7.24 (t, J=7.9), 3.47 (s, 3H).