1-(2-Bromophenyl)ethyl behenate → 1-(2-Bromophenyl)ethan-1-ol

HRID 1939758

반응식

HRID 1939758 반응식
C([O:24][CH:25]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[Br:33])[CH3:26])(=O)CCCCCCCCCCCCCCCCCCCCC>O>[Br:33][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[C@@H:25]([OH:24])[CH3:26]

참가 물질

3

반응물 1

HCID 214681721-(2-Bromophenyl)ethyl behenate

생성물 1

HCID 69503311-(2-Bromophenyl)ethan-1-ol수율 88%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Interesterification was carried out by using 3 g of Lipase QL, 50 g of (R,S)-1-(2-bromophenyl)ethanol, and 150 g of tribehen at 120° C. for 20 hours in the same manner as in Example 12. The water content of the reaction system was 0.01% by weight, and 90% of the lipase particles had a particle size of 30 to 50 μm. Gas chromatography of the reaction mixture revealed that 44 mol % of (R,S)-1-(2-bromophenyl)ethanol had been converted to 1-(2-bromophenyl)ethyl behenate. The reaction mixture was treated in the same manner as in Example 12, and the filtrate was subjected to simple distillation at 110° C. and 5 mmHg to recover unreacted (S)-(-)-1-(2-bromophenyl)ethanol (yield: 88%; chemical purity: 99.9%; optical purity: 99% ee or higher).

후처리

  1. customat 120° C.
  2. customfor 20 hours
  3. additionThe reaction mixture was treated in the same manner as in Example 12
  4. distillationthe filtrate was subjected to simple distillation at 110° C.

출처 및 근거

ORD 기록
ord-cc88f2f51df940b8936dbb7e7a8ad1f1
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05696299

연결된 노트

불러오는 중…