Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 2-Benzylpropane-1,3-diol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Diethyl 2-benzylpropanedioate | HCID 69090 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2-Benzylpropane-1,3-diol | HCID 520241 | 63.6% |
반응 단계
Slowly add a solution of diethyl 2-benzylmalonate (20 g) in Et2O (300 mL) to a slurry of LiAlH4 (6 g) in Et2O (300 mL), then heat the reaction mixture at reflux for 14 h. Carefully add 4N NaOH to the reaction mixture until there is no precipitate, then extract with EtOAc. Concentrate the organic layer and purify the crude product on a silica gel column, eluting with EtOAc to obtain 2-benzyl-1,3-propanediol (8.45 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05698548 |
| 출처 데이터셋 | uspto-grants-1997_12 |
| ORD ID | ord-88bac1799d3a4ae4a0f6d84a9b4445e2 |
| 출처 메모 | uspto-grants-1997_12 |