참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | o-Toluenesulfonyl chloride | HCID 8623 | — |
| 반응물 | Methyl Glycolate | HCID 66774 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl toluenesulfonyloxyacetate | HCID 86751745 | 98.3% |
반응 단계
18 g (0.2 mol) of methyl hydroxyacetate and 20.2 g (0.2 mol) of triethylamine are first introduced into 300 ml of dichloromethane at 0° C. 41.9 g (0.22 mol) of toluenesulfonyl chloride are then added at this temperature in small portions. Stirring of the batch at 0° C. is continued overnight. Ice water is added, the phases are separated, and the aqueous phase is extracted three times with dichloromethane. The combined organic phases are washed once with water, dried, and the solvent is removed on a rotary evaporator. 48 g (98% of theory) of methyl toluenesulfonyloxyacetate having a GC content of 96% are isolated as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05698735 |
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| 출처 데이터셋 | uspto-grants-1997_12 |
|---|
| ORD ID | ord-49cbc3da55944ccc97d427074c032aa5 |
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| 출처 메모 | uspto-grants-1997_12 |
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