Trifluoroacetic acid → [[4-[[N-[3-(piperidin-4-yl)propionyl]-N-methylamino]acetyl]-o-phenylene]dioxy]diacetic acid trifluoroacetate

HRID 1940376노트

반응식

C([C:5](C(C)(C)C)([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[O:37])[CH2:17][N:18]([C:20](=[O:36])[CH2:21][CH2:22][CH:23]2[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]2)[CH3:19])=[CH:12][C:11]=1[O:38][CH2:39][C:40]([O-:42])=[O:41])[C:6]([O-:8])=[O:7])(C)(C)C.[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50]>>[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50].[NH:26]1[CH2:27][CH2:28][CH:23]([CH2:22][CH2:21][C:20]([N:18]([CH2:17][C:16]([C:13]2[CH:14]=[CH:15][C:10]([O:9][CH2:5][C:6]([OH:8])=[O:7])=[C:11]([O:38][CH2:39][C:40]([OH:42])=[O:41])[CH:12]=2)=[O:37])[CH3:19])=[O:36])[CH2:24][CH2:25]1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 21466012Di-t-butyl[[4-[[N-[3-(1-t-butyloxycarbonylpiperidin-4-yl)propionyl]-N-methylamino]acetyl]-o-phenylene]dioxy]diacetate

생성물 1

HCID 67624455[[4-[[N-[3-(piperidin-4-yl)propionyl]-N-methylamino]acetyl]-o-phenylene]dioxy]diacetic acid trifluoroacetate

실험 절차

The solution of 250 mg of the compound prepared in (a) in 2 ml of trifluoroacetic acid was stirred at room temperature for 3 hours. Afer the solvent was evaporated under reduced pressure, ether was added and deposited crystals were collected by filtration to give 168 mg of the title compound.

후처리

customAfer the solvent was evaporated under reduced pressure, ether
additionwas added
filtrationwere collected by filtration

출처 및 근거

ORD 기록: ord-ecefebe87511418ebf5eae66ff8c7423
출처 데이터셋: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05698692

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