Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Benzylglycine ethyl ester → N-benzyl-N-[3-(4,5,7-trifluorobenzothiazol-2-yl)propionyl]-glycine ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Benzylglycine ethyl ester | HCID 80908 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 3-(4,5,7-Trifluorobenzothiazol-2-yl)propionic acid | HCID 21463529 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-benzyl-N-[3-(4,5,7-trifluorobenzothiazol-2-yl)propionyl]-glycine ethyl ester | HCID 21463502 | 78% |
반응 단계
To methylene chloride (10 ml) was added 3-(4,5,7-trifluorobenzothiazol-2-yl)propionic acid (522 mg, 2 mmol) obtained in Example 3-i), WSC.HCl (422 mg, 2.2 mmol) and N-benzylglycine ethyl ester (386 mg, 2 mmol) and the mixture was stirred for 15 hours at room temperature. The reaction mixture was washed with 7% hydrochloric acid and water successively. The organic layer was dried and evaporated. The resulting residue was purified on a silica gel column to give N-benzyl-N-[3-(4,5,7-trifluorobenzothiazol-2-yl)propionyl]-glycine ethyl ester (680 mg, 78%) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05700819 |
| 출처 데이터셋 | uspto-grants-1997_12 |
| ORD ID | ord-7897ee35011b4edf81e1bda2a1c1957d |
| 출처 메모 | uspto-grants-1997_12 |