Pyridine → N-chloroacetyl-N-phenylglycine methyl ester

HRID 1940618

반응식

HRID 1940618 반응식
[CH3:1][O:2][C:3](=[O:12])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.N1C=CC=CC=1.[Cl:19][CH2:20][C:21](Cl)=[O:22]>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:12])[CH2:4][N:5]([C:21](=[O:22])[CH2:20][Cl:19])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6577Chloroacetyl chlorideHCID 571509Methyl 2-(phenylamino)acetate

생성물 1

HCID 21463537N-chloroacetyl-N-phenylglycine methyl ester수율 70%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To methylene chloride (20 ml) was added N-phenylglycine methyl ester (2.02 g, 10 mmol) and pyridine (1.58 g, 20 mmol) and the mixture was stirred. To the mixture was added dropwise a solution of chloroacetyl chloride (1.13 g, 10 mmol) in methylene chloride (3 ml) at room temperature and the resulting mixture was stirred for 15 hours, washed with water, dried and evaporated. The resultant residue was crystallized from isopropyl ether to give N-chloroacetyl-N-phenylglycine methyl ester (1.67 g, 70%) as a colorless powder.

후처리

  1. stirringthe resulting mixture was stirred for 15 hours
  2. washwashed with water
  3. customdried
  4. customevaporated
  5. customThe resultant residue was crystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-fa0f3908ea2d449ca8c20449227196e8
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05700819

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