Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → Stilbene oxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Benzene, (diazomethyl)- | HCID 136601 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Acetic acid, rhodium(2+) salt | HCID 21674 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Stilbene oxide | HCID 28649 | 58% |
반응 단계
Phenyl diazomethane (1 mmol in 6 ml of t-butylmethylether) was added to a stirred solution of a sulphide of formula (B) wherein R' is hydrogen (0.2 mmol), rhodium (II) acetate (4.0 mg, 0.01 mmol) and benzaldehyde (1 mmol) in dichloromethane (4 ml) at room temperature over a period of 24 hours. After the addition was complete the solvent was removed in vacuo and the residue was chromatographed over silica [eluent dichloromethane:petrol (2:3)] to give the titled compound in 58% yield and 11% ee.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05703246 |
| 출처 데이터셋 | uspto-grants-1997_12 |
| ORD ID | ord-7c80eec67a9c44569f07a42c0ae4603b |
| 출처 메모 | uspto-grants-1997_12 |