Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Naltrexone Base → Benzyl Alcohol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Naltrexone Base | HCID 21159611 | — |
| 용매 | Benzyl Alcohol | HCID 244 | — |
| 생성물 | Benzyl Alcohol | HCID 244 | 70% |
| 생성물 | 3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one | HCID 4428 | 30% |
반응 단계
A 1 kg batch of naltrexone microspheres were prepared as follows. Polymer solution was formed by dissolving 75:25 DL PLGA (poly(lactide)-co-glycolide) in ethyl acetate (EtAc) to form a solution of 16.7% polymer and 83.3% EtAc. A naltrexone solution was formed by dissolving naltrexone base in benzyl alcohol (BA) to form a solution of 30% naltrexone base anhydrous and 70% BA. The polymer solution and the naltrexone solution were mixed together to form a drug/polymer solution that was the “organic” or “oil” phase of the emulsion.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08389540B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-87e7e389865e429790b5077a8a93d144 |
| 출처 메모 | uspto-grants-2013_03 |