Potassium Carbonate → N-(4-hydroxybutyl)benzothiazole-2-carboxamide

HRID 1942382노트

반응식

HRID 1942382 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10](Cl)=[O:11].[NH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[OH:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:10]([C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)=[O:11]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 258684-Amino-1-butanolHCID 2776254Benzothiazole-2-carbonyl chloride

생성물 1

HCID 66937473N-(4-hydroxybutyl)benzothiazole-2-carboxamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1 g (5 mmol) benzothiazol-2-carbonyl chloride, 542 mg (6 mmol) 4-aminobutan-1-ol and 1.4 g (10 mmol) K2CO3 in acetonitrile is stirred for three days at room temperature. The solvent is evaporated and the product is dissolved in ethyl acetate and washed with 2N HCl and water. After evaporation of the solvent the yellow semisolid is crystallized from ethyl acetate.

후처리

  1. customThe solvent is evaporated
  2. dissolutionthe product is dissolved in ethyl acetate
  3. washwashed with 2N HCl and water
  4. customAfter evaporation of the solvent the yellow semisolid
  5. customis crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-9ce5a60c887c4de9a7f58f32a483d012
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389555B2

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