Triethylamine → N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide

HRID 1942388노트

반응식

HRID 1942388 반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([O:18][CH:19]([O:24][CH2:25][CH3:26])[CH2:20][CH2:21][CH2:22][NH2:23])[CH3:17].C(N(CC)CC)C.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[CH2:25]([O:24][CH:19]([O:18][CH2:16][CH3:17])[CH2:20][CH2:21][CH2:22][NH:23][C:13]([N:10]1[CH2:11][CH2:12][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1)=[O:14])[CH3:26]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 10340Sodium CarbonateHCID 806724,4-DiethoxybutylamineHCID 866513114-Phenylpiperidine-1-carbonyl chloride

생성물 1

HCID 66937642N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 895 mg (4 mmol) of 4-phenylpiperidine-1-carbonylchloride in 4 mL dichloromethane is added to 0.69 mL (4 mmol) 4,4-diethoxybutylamine and 1.68 mL (12 mmol) of triethylamine dissolved in 20 mL of dichloromethane. The mixture is stirred overnight. 20 mL of saturated sodium carbonate solution is added. The organic phase is separated, dried with sodium sulfate and the solvent evaporated.

후처리

  1. customThe organic phase is separated
  2. dry with materialdried with sodium sulfate
  3. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-7751316ceb004643bc0cc65ccacf0998
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389555B2

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