Triethylamine → 5-[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-pentanoic acid naphthalen-2-ylamide

HRID 1942395노트

반응식

HRID 1942395 반응식
[CH2:1]([NH:4][CH:5]1[CH2:13][CH2:12][C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6]1)[CH2:2][CH3:3].[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[NH:24][C:25](=[O:31])[CH2:26][CH2:27][CH2:28][CH2:29]Br.C(N(CC)CC)C>CC(C)=O>[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[NH:24][C:25](=[O:31])[CH2:26][CH2:27][CH2:28][CH2:29][N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:13][CH2:12][C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 18705889Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amineHCID 669374455-Bromo-pentanoic acid naphthalen-2-ylamide

생성물 1

HCID 669374525-[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-pentanoic acid naphthalen-2-ylamide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

9 is prepared from 1C and 9A using the same method as for 6 with acetone as solvent and triethylamine as base. Reaction temperature is 50° C. After evaporation of the solvent the residue is suspended in water, alkalized with sodium hydroxide solution and extracted three times with dichloromethane. After evaporation of the combined organic phases the product is crystallized as salt of maleic acid from acetonitrile/diethylether.

후처리

  1. customReaction temperature
  2. customis 50° C
  3. customAfter evaporation of the solvent the residue
  4. extractionextracted three times with dichloromethane
  5. customAfter evaporation of the combined organic phases the product
  6. customis crystallized as salt of maleic acid from acetonitrile/diethylether

출처 및 근거

ORD 기록
ord-72f48c4767c14a9d8d616a8a90e2683e
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389555B2

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