Isopropanol → 5-Bromo-3-chloro-2-[(propan-2-yl)oxy]pyridine

HRID 1942675노트

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HRID 1942675 반응식
[CH3:1][C:2](C)([O-:4])[CH3:3].[K+].CC(O)C.[Br:11][C:12]1[CH:13]=[C:14]([Cl:19])[C:15](Cl)=[N:16][CH:17]=1>>[Br:11][C:12]1[CH:13]=[C:14]([Cl:19])[C:15]([O:4][CH:2]([CH3:3])[CH3:1])=[N:16][CH:17]=1

참가 물질

4

반응물 3

HCID 3776IsopropanolHCID 127477605-Bromo-2,3-dichloropyridineHCID 23665647Potassium tert-butoxide

생성물 1

HCID 584941335-Bromo-3-chloro-2-[(propan-2-yl)oxy]pyridine수율 101%

반응 조건

온도
95 °C

실험 절차

Potassium tert-butoxide (25.7 g, 229 mmol) was added to 2-propanol (100 mL, 57.3 mmol) and the solution was stirred at 95° C. for 3 h, then 5-bromo-2,3-dichloropyridine (13 g, 57.3 mmol) was added. This reaction was refluxed overnight. The reaction mixture was cooled to room temperature and partitioned between ethyl acetate and water. The organic phase was washed with water and saturated brine, dried over sodium sulphate and evaporated in vacuo to afford the crude product 5-bromo-3-chloro-2-[(1-methylethyl)oxy]pyridine (D107) (14.5 g), which was used directly without further purification.

후처리

  1. temperatureThis reaction was refluxed overnight
  2. temperatureThe reaction mixture was cooled to room temperature
  3. custompartitioned between ethyl acetate and water
  4. washThe organic phase was washed with water and saturated brine
  5. dry with materialdried over sodium sulphate
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-e484f019ca7e4b03ba5fd92bb648e3c8
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389508B2

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