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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Trifluoroacetic acid → N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-phenyl-2-thioxoimidazolidine-1-carboxamide

HRID 1942810
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HRID 1942810 반응식
C(O)(C(F)(F)F)=O.[F:8][C:9]1[CH:43]=[C:42]([NH:44][C:45]([N:47]2[CH2:51][CH2:50][N:49]([C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=3)[C:48]2=[S:58])=[O:46])[CH:41]=[CH:40][C:10]=1[O:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]2[CH:18]=[C:19]([C:21]3[N:26]=[CH:25][C:24]([CH2:27][N:28]([CH2:36][CH2:37][O:38][CH3:39])C(=O)OC(C)(C)C)=[CH:23][CH:22]=3)[S:20][C:13]=12>C(Cl)Cl>[F:8][C:9]1[CH:43]=[C:42]([NH:44][C:45]([N:47]2[CH2:51][CH2:50][N:49]([C:52]3[CH:53]=[CH:54][CH:55]=[CH:56][CH:57]=3)[C:48]2=[S:58])=[O:46])[CH:41]=[CH:40][C:10]=1[O:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]2[CH:18]=[C:19]([C:21]3[CH:22]=[CH:23][C:24]([CH2:27][NH:28][CH2:36][CH2:37][O:38][CH3:39])=[CH:25][N:26]=3)[S:20][C:13]=12
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 57919539Tert-butyl (6-(7-(2-fluoro-4-(3-phenyl-2-thioxoimidazolidine-1-carboxamido)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate

생성물 1

HCID 25270231N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-phenyl-2-thioxoimidazolidine-1-carboxamide수율 85.2%

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

TFA (1 ml, 12.98 mmol) was added to a suspension of 302 (0.093 g, 0.128 mmol) in DCM (1.000 ml) and the mixture was stirred at room temperature for 2 h. The reaction mixture was then concentrated under reduced pressure, the residue was dissolved in DCM, washed with 1N NaOH solution, water, dried over anhydrous sodium sulfate and concentrated affording title compound 303 (0.0714 g, 0.109 mmol, 85% yield) as white solid.

후처리

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. dissolutionthe residue was dissolved in DCM
  3. washwashed with 1N NaOH solution, water
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9b8e1adbf50d4f2e9fdcc73333849597
출처 데이터셋
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08389541B2

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