Diisopropylamine → HCID 66704174, 화합물

HRID 1943010노트

반응식

HRID 1943010 반응식
[O:1]=[C:2]1[C@@:6]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][C:4](=[O:17])[NH:3]1.[CH:18]([NH:21][CH:22]([CH3:24])[CH3:23])([CH3:20])[CH3:19].CCCCCC>C(OCC)(=O)C>[CH:18]([NH:21][CH:22]([CH3:24])[CH3:23])([CH3:20])[CH3:19].[O:1]=[C:2]1[C@@:6]([N:12]2[CH:13]=[CH:14][CH:15]=[CH:16]2)([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][C:4](=[O:17])[NH:3]1

참가 물질

5

반응물 3

HCID 7912DiisopropylamineHCID 8058HexaneHCID 10823690Ethyl (3R)-2,5-dioxo-3-(1H-pyrrol-1-yl)-3-pyrrolidinecarboxylate

생성물 1

HCID 66704174HCID 66704174, 화합물수율 60%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

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온도
40 °C

실험 절차

Ethyl (R)-2,5-dioxo-3-(pyrrol-1-yl)pyrrolidine-3-carboxylate (220 mg) was dissolved in ethyl acetate (1 ml) and thereto was added diisopropylamine (0.130 ml). To this solution was added hexane (1 ml) and the resulting white suspension was warmed at 40° C. to give a homogeneous solution. This mixture was allowed to stand at room temperature and precipitated crystal was collected by filtering to give ethyl (R)-2,5-dioxo-3-(pyrrol-1-yl)pyrrolidine-3-carboxylate diisopropylamine salt (198 mg, 60%) as crystal.

후처리

  1. customto give a homogeneous solution
  2. customto stand at room temperature
  3. customprecipitated crystal
  4. customwas collected
  5. filtrationby filtering

출처 및 근거

ORD 기록
ord-095727a490014f0ab45ac4d8c621cf1d
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389742B2

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