Methanol → Methyl 6-Bromohexanoate

HRID 19431

반응식

[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].[CH3:10]O>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:10])=[O:8]

참가 물질

반응물 2

HCID 887Methanol

HCID 202106-Bromohexanoic acid

생성물 1

HCID 4170292Methyl 6-Bromohexanoate수율 99%

실험 절차

To a 1 L round bottom flask, charged with 20 g (102.5 mmol) of 6-bromohexanoic acid and 500 mL of methanol, was bubbled hydrogen chloride gas for 2-3 minutes. The mixture was stirred at room temperature for 4 hours and concentrated to afford 21.0 g of the product as a yellow oil (99%): 1H-NMR (200 MHz, d6-DMSO); 3.57 (s, 3H), 3.51 (t, 2H), 2.30 (t, 2H), 1.78 (pentet, 2H), and 1.62-1.27 (m, 4H) ppm.

후처리

customwas bubbled hydrogen chloride gas for 2-3 minutes
concentrationconcentrated

출처 및 근거

ORD 기록: ord-47fee8242e1c4d13bc75ee30394f7a72
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07744853B2

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