Methanol → Propanoic acid, 2-bromo-3-(phenylmethoxy)-, methyl ester

HRID 1943142노트

반응식

HRID 1943142 반응식
[Br:1][CH:2]([CH2:6][O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4].S(Cl)(Cl)=O.[CH3:19]O>>[Br:1][CH:2]([CH2:6][O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5][CH3:19])=[O:4]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 109562653-(Benzyloxy)-2-bromopropanoic acid

생성물 1

HCID 11011152Propanoic acid, 2-bromo-3-(phenylmethoxy)-, methyl ester수율 99%

실험 절차

A solution of 2-bromo-3-[(phenylmethyl)oxy]propanoic acid (6 g, 23.2 mmol) in methanol (40 ml) at rt under argon was treated with thionyl chloride (1.7 ml, 23.2 mmol) and the reaction was then stirred at rt for 3 h and then evaporated to give product as a yellow oil (6.3 g, 99%).

후처리

  1. customevaporated

출처 및 근거

ORD 기록
ord-c81117c412504c65aeee6c5632869be6
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389524B2

반응 노트

불러오는 중…