Trifluoroacetic acid → (R)-2-Amino-3-cyclohexylpropanoic acid trifluoroacetate

HRID 1943297노트

반응식

HRID 1943297 반응식
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C([NH:15][C@H:16]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:17]([OH:19])=[O:18])(OC(C)(C)C)=O>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[NH2:15][C@H:16]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:17]([OH:19])=[O:18]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 2755927(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-cyclohexylpropanoic acid

생성물 1

HCID 68547671(R)-2-Amino-3-cyclohexylpropanoic acid trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5 ml of TFA were added to a solution of (R)-N-Boc-2-amino-3-cyclohexylpropanoic acid (3.0 g, 11.1 mmol) in 20 ml of CH2Cl2, and the mixture was stirred at RT overnight. After deprotection was complete, the CH2Cl2 was evaporated off, and the remaining solid was mixed with 50 ml of H2O and lyophilized. Yield: 2.84 g (90%) of (R)-2-amino-3-cyclohexylpropanoic acid trifluoroacetate as colorless solid.

후처리

  1. customthe CH2Cl2 was evaporated off
  2. additionthe remaining solid was mixed with 50 ml of H2O

출처 및 근거

ORD 기록
ord-e1635b8dee454b27a6afff92f3283f61
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389764B2

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