Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1943489생성일: 2026년 10월 27일
Ethylamine → 6-chloro-8-(ethylamino)-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide
https://huagongshe.com/reaction/1943489
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylamine | HCID 6341 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 8-Bromo-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide | HCID 59624495 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 6-chloro-8-(ethylamino)-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide | HCID 59624729 | 76.6% |
반응 단계
A suspension of 5A (80 mg, 0.245 mmol), ethanamine (0.6 mL, 1.200 mmol, 2 M/THF) and DIEA (0.086 mL, 0.491 mmol) in NMP (0.7 mL) was heated at 80° C. for 5 h. The reaction mixture was cooled to room temperature and the solid was collected by filtration and washed with a small amount of DCM to give 6-chloro-8-(ethylamino)-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide as a yellow solid 62.8 mg. HPLC Rt=2.517 minutes (Chromolith SpeedROD 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA, 4 min gradient, monitored at 220 nm). [M+H]=335.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08389527B2 |
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| 출처 데이터셋 | uspto-grants-2013_03 |
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| ORD ID | ord-cd8ca855d28f4b5782930fb07458e03c |
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| 출처 메모 | uspto-grants-2013_03 |
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