5-Bromothiophene-2-carbaldehyde → HCID 58160688, 화합물

반응식

[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13](B(O)O)=[C:12]([F:19])[CH:11]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].Br[C:21]1[S:25][C:24]([CH:26]=[O:27])=[CH:23][CH:22]=1>>[F:19][C:12]1[CH:11]=[C:10]([C:7]2[CH:8]=[CH:9][C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][CH:6]=2)[CH:15]=[CH:14][C:13]=1[C:21]1[S:25][C:24]([CH:26]=[O:27])=[CH:23][CH:22]=1

참가 물질

반응물 2

HCID 784285-Bromothiophene-2-carbaldehyde

HCID 53402576B-(3-Fluoro-4'-propyl(1,1'-biphenyl)-4-yl)boronic acid

생성물 1

HCID 58160688HCID 58160688, 화합물

실험 절차

5-(3-Fluoro-4′-propylbiphenyl-4-yl)thiophene-2-carbaldehyde is prepared analogously to Example 3 by Suzuki coupling of 4′-propyl-3-fluoro-4-biphenylboronic acid to 5-bromothiophene-2-carbaldehyde.

출처 및 근거

ORD 기록: ord-9f33c8f6555049909b7eb0bbac652398
출처 데이터셋: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08394293B2

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