Sodium Carbonate → Sevelamer carbonate
반응식
[C:1](=[O:4])([O-:3])[O-:2].[Na+].[Na+].[CH2:7]=[CH:8][CH2:9][NH2:10].[CH2:11]1[O:13][CH:12]1[CH2:14][Cl:15].Cl>O>[CH2:7]=[CH:8][CH2:9][NH3+:10].[CH2:11]1[O:13][CH:12]1[CH2:14][Cl:15].[C:1]([O-:4])([OH:3])=[O:2]참가 물질
4
반응 조건
- 온도
- 32.5 °C
실험 절차
A 5 L reactor, equipped with a mechanical stirrer, temperature probe, dropping funnel and a condenser topped with a nitrogen inlet, was charged with water (4 L), sodium carbonate (250 g), and the solution was brought at 35° C. Sevelamer hydrochloride (400 g) are added portion wise for 1 h, in portions of 20 g each, while stirring, maintaining the temperature from 30 to 35° C. The solid is then filtered and suspended in water (3 L), at 30-35° C. The mixture is allowed to stir for 20 minutes. The solid was filtered again and rinsed with water until disappearance of chloride ions. The product is dried under reduced pressure at 70° C. to afford Sevelamer carbonate (290 g), with a phosphate binding capacity of 17.2-17.6 mEq/g.