Trifluoroacetic acid ethanol → ethyl (2E)-4-aminobut-2-enoate trifluoroacetate

HRID 1943623노트

반응식

HRID 1943623 반응식
C([N:3](C=O)[CH2:4]/[CH:5]=[CH:6]/[C:7]([O:9][CH2:10][CH3:11])=[O:8])=O.[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17].C(O)C>>[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17].[NH2:3][CH2:4]/[CH:5]=[CH:6]/[C:7]([O:9][CH2:10][CH3:11])=[O:8]

참가 물질

3

반응물 2

HCID 19378329Trifluoroacetic acid ethanolHCID 58465259ethyl (2E)-4-(diformylamino)but-2-enoate

생성물 1

HCID 72699081ethyl (2E)-4-aminobut-2-enoate trifluoroacetate

실험 절차

A solution of ethyl (2E)-4-(diformylamino)but-2-enoate (XV) (0.89 mg, 4.8 mmol) in a mixture trifluoroacetic acid-ethanol (absolute) (2:1, 10 mL) was stirred under reflux overnight (the reaction was followed by LC-MS and stopped when complete conversion was achieved). The solvent was evaporated under vacuum to obtain compound ethyl (2E)-4-aminobut-2-enoate trifluoroacetate (IV) as brown oil (undetermined yield), which was used without further purification in the next step.

후처리

  1. temperatureunder reflux overnight (the reaction
  2. customThe solvent was evaporated under vacuum
  3. customto obtain

출처 및 근거

ORD 기록
ord-c53ed8279bff4145b331eca797379488
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394802B2

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